This article reports the first clinical case using topical exosomes derived from Lactobacillus plantarum to treat active acne. After 4 weeks of application, the patient showed marked reductions in papules, pustules, and inflammation, with no irritation or side effects—suggesting exosomes may be a promising non-antibiotic option for acne management.

This study shares clinical insights on hybrid filler protocols combining hyaluronic acid (HA) with hyperdiluted calcium hydroxylapatite (CaHA). The premixed formulation, injected with a cannula in fan or retrograde technique, provided improved skin quality, hydration, and firmness. The article includes tips for product ratios, areas of use, and adverse event prevention.

This case series explores the use of a 675-nm diode laser for the treatment of mixed-type melasma in patients with Fitzpatrick phototypes III to V. Four women underwent one or two sessions using the RedTouchPro laser. The protocol resulted in notable improvements in both pigmentary and vascular components, with minimal discomfort and no significant side effects. Image-based assessment using the LifeViz system showed enhanced brightness, texture, and skin uniformity. The laser’s high affinity for melanin and collagen, along with integrated cooling, ensures a safe and effective approach to melasma in darker skin tones, even during summer months.

This multicenter study evaluated the effectiveness and tolerability of a protocol combining a microneedle-based intradermal delivery device with a poly-revitalizing solution containing free hyaluronic acid. Thirty-three patients underwent three full-face treatments at monthly intervals. Significant improvement was observed in skin texture, wrinkles, and periorbital elasticity, with high levels of satisfaction and minimal side effects. The approach was particularly well-suited for delicate facial areas like the eyelids, supporting its use in routine anti-aging practice.

This study validates a 4-point injection protocol for non-surgical rhinoplasty using hyaluronic acid fillers. It evaluates aesthetic results, stability (via Arnett analysis), and patient satisfaction. The technique allows temporary correction of nasal deformities while minimizing risks, offering a strategic alternative to revision rhinoplasty in selected cases.

This study offers practical clinical guidelines on using hyaluronidase to dissolve hyaluronic acid (HA) fillers. It compares dissolution rates in monophasic vs. biphasic gels, dosage recommendations, and injection techniques. The results support direct infiltration into the filler mass for faster, safer resolution, especially in complication management.

This paper evaluates a new high-powered 675-nm laser for various dermatologic indications, including pigmented lesions, acne scars, and aging skin. Both in vitro and clinical data confirm significant collagen stimulation, safety, and reduced treatment time. The laser showed excellent patient satisfaction and no adverse effects across all protocols.

Pamela et al., including Vitale, present a prospective case series evaluating the safety and efficacy of a 675 nm non-ablative laser for melasma in patients with Fitzpatrick skin types IV–V. Three Indonesian women underwent three monthly sessions, showing significant reductions in mMASI scores and visible improvement without adverse effects. The study highlights the laser’s dual action on melanin and collagen with a favorable safety profile in darker phototypes, suggesting its potential as a safe, effective option for melasma in skin of color.

This synergistic protocol combines soft peeling with controlled microneedling to treat early signs of facial aging. The two-step approach promotes dermal remodeling and improves skin texture with minimal downtime. Based on a case series, the method demonstrated measurable improvements in brightness, tone, and fine lines—offering a safe, effective, and non-invasive strategy for facial rejuvenation in daily clinical practice.

This article reports the first clinical case using topical exosomes derived from Lactobacillus plantarum to treat active acne. After 4 weeks of application, the patient showed marked reductions in papules, pustules, and inflammation, with no irritation or side effects—suggesting exosomes may be a promising non-antibiotic option for acne management.